The Advancing Clinical Trial Readiness (ACTR) Initiative, led by ARPA-H’s Resilient Systems Office (RSO), aims to transform clinical trials by developing a robust, efficient, and decentralized trial infrastructure. The core focus of the effort is to create the tools, network, and infrastructure necessary for decentralized and on-demand clinical trials that would enable 90% of eligible Americans to participate in clinical trials within 30 minutes of their home. This includes automating data extraction and synchronization between Electronic Health Records (EHRs) and case report forms (CRFs), standardizing data collection, and enhancing patient enrollment and retention, particularly in underserved and non-traditional sites. By developing technical approaches that facilitate a “network of networks,” ACTR will enable Contract Research Organizations (CROs) to interoperate and extend into different non-traditional sites, geographies, and underserved populations, making clinical trials more accessible, representative, and cost-effective.

The initiative will kick off with a hybrid Proposers’ Day on January 16 at 10:00 a.m. ET in the New Brunswick, N.J. area. The ACTR Proposers’ Day will feature presentations by ARPA-H, including technical presentations covering the ACTR effort as well as informational sessions during which participant questions will be answered.

Interested participants must register in advance through the registration website https://solutions.arpa-h.gov/ACTR