The Advancing Clinical Trial Readiness (ACTR) Initiative, led by ARPA-H’s Resilient Systems Office (RSO), aims to transform clinical trials by developing a robust, efficient, and decentralized trial infrastructure. The core focus of the effort is to create the tools, network, and infrastructure necessary for decentralized and on-demand clinical trials that would enable 90% of eligible Americans to participate in clinical trials within 30 minutes of their home.